Automated tracking and analysis of centrosomes in early Caenorhabditis elegans embryos.

Jaensch S, Decker M, Hyman AA, Myers EW

The centrosome is a dynamic structure in animal cells that serves as a microtubule organizing center during mitosis and also regulates cell-cycle progression and sets polarity cues. Automated and reliable tracking of centrosomes is essential for genetic screens that study the process of centrosome assembly and maturation in the nematode Caenorhabditis elegans.