Effects of immunosuppression on alpha and beta cell renewal in transplanted mouse islets.

Krautz C, Wolk S, Steffen A, Knoch KP, Ceglarek U, Thiery J, Bornstein S, Saeger HD, Solimena M, Kersting S

Immunosuppressive drugs used in human islet transplantation interfere with the balance between beta cell renewal and death, and thus may contribute to progressive graft dysfunction. We analysed the influence of immunosuppressants on the proliferation of transplanted alpha and beta cells after syngeneic islet transplantation in streptozotocin-induced diabetic mice.

Journal, Issue, Date: Diabetologia 2013 Jul 27;56(7):1596-604
Year: 2013
Research Area: Medical Biology
PubMed ID: 23532258
PubMed link: PubMed

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