Biopolis Dresden Imaging Platform

CMCB - Molecular Imaging and Manipulation Facility

The Molecular Imaging and Manipulation Facility (MIM) provides high-end imaging and manipulation devices combined with profound knowledge of image and data analysis to identify and characterize structure-function-relationships on a molecular level.

In terms of imaging, this comprises atomic force microscopy (AFM) as well as optical imaging with single-molecule localization-based superresolution (STORM/PALM/...), TIRF, as well as standard widefield epi-fluorescence imaging. Single-molecule techniques like single-particle tracking (SPT) and Förster resonance energy transfer (FRET) are offered along with the necessary analysis tools. The Interferometric Scattering Microscopy (iSCAT) technique is especially interesting for label-free detection of biomolecules or high-speed single-molecule tracking. Molecular manipulation is achieved by force application with AFM or optical tweezers.

Apart from user training and technical support the MIM Facility offers measurement service, image-analysis support, as well as customized optical microscopy design.


  • TIRF single-molecule fluorescence imaging
  • Super-resolution localization microscopy (STORM/PALM/...)
  • Spinning Disk 3D confocal imaging
  • Fluorescence recovery after photobleaching (FRAP) measurements
  • Conventional wide-field fluorescence microscopy
  • Atomic force microscopy (AFM)
  • Optical tweezers
  • Interferometric Scattering Microscopy (iSCAT)
  • soon: FRET and FCS measurements


  • User training and technical support
  • Image analysis
  • Customization of commercial and home-built setups
  • Measurement service


B CUBE - Center for Molecular Bioengineering
Technische Universitaet Dresden
Tatzberg 41
01307 Dresden

e-mail: jens.ehrig[at]
+49 - 351 - 463 43036
web: MIM webpage

How to become a user

Please get in touch with us if you are interested in using the facility.

Facility Members