Biopolis Dresden Imaging Platform

Hematopoietic stem cells in co-culture with mesenchymal stromal cells--modeling the niche compartments in vitro.

Jing D, Fonseca AV, Alakel N, Fierro FA, Muller K, Bornhauser M, Ehninger G, Corbeil D, Ordemann R

Hematopoietic stem cells located in the bone marrow interact with a specific microenvironment referred to as the stem cell niche. Data derived from ex vivo co-culture systems using mesenchymal stromal cells as a feeder cell layer suggest that cell-to-cell contact has a significant impact on the expansion, migratory potential and 'stemness' of hematopoietic stem cells. Here we investigated in detail the spatial relationship between hematopoietic stem cells and mesenchymal stromal cells during ex vivo expansion.

Fig.1 taken from Jing et al, 2010.
  • Haematologica 2010 Apr 09;95(4):542-50
  • 2010
  • Medical Biology
  • 20145267
  • PubMed

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