Biopolis Dresden Imaging Platform

Alignment and cell-matrix interactions of human corneal endothelial cells on nanostructured collagen type I matrices.

Gruschwitz R, Friedrichs J, Valtink M, Franz CM, Müller DJ, Funk RH, Engelmann K

To use nanoscopically defined, two-dimensional matrices assembled from aligned collagen type I fibrils as a sheet substratum for in vitro cultivation of human corneal endothelial cells (HCECs). To assess the effect of matrix architecture on HCEC morphology and to characterize integrin-mediated HCEC-matrix interaction.

Fig.1 taken from Gruschwitz et al, 2010.
  • Invest. Ophthalmol. Vis. Sci. 2010 Dec 14;51(12):6303-10
  • 2010
  • Medical Biology
  • 20631237
  • PubMed

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