Biopolis Dresden Imaging Platform

Intercellular coupling regulates the period of the segmentation clock.

Herrgen L, Ares S, Morelli LG, Schröter C, Jülicher F, Oates AC

Coupled biological oscillators can tick with the same period. How this collective period is established is a key question in understanding biological clocks. We explore this question in the segmentation clock, a population of coupled cellular oscillators in the vertebrate embryo that sets the rhythm of somitogenesis, the morphological segmentation of the body axis. The oscillating cells of the zebrafish segmentation clock are thought to possess noisy autonomous periods, which are synchronized by intercellular coupling through the Delta-Notch pathway. Here we ask whether Delta-Notch coupling additionally influences the collective period of the segmentation clock.

Fig.2 taken from Herrgen et al, 2010.
  • Curr. Biol. 2010 Jul 27;20(14):1244-53
  • 2010
  • Developmental Biology
  • 20637620
  • PubMed

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