Biopolis Dresden Imaging Platform

Oxygen tension plays a critical role in the hematopoietic microenvironment in vitro.

Jing D, Wobus M, Poitz DM, Bornhäuser M, Ehninger G, Ordemann R

In the bone marrow mesenchymal stromal cells and osteoblasts form functional niches for hematopoietic stem and progenitor cells. This microenvironment can be partially mimicked using in vitro co-culture systems. In this study, we examined the oxygen tension in three distinct compartments in a co-culture system of purified CD34(+) cells and mesenchymal stromal cells with regard to different spatial localizations.

Fig.1 taken from Jing et al, 2012.
  • Haematologica 2012 Mar 04;97(3):331-9
  • 2012
  • Medical Biology
  • 22058205
  • PubMed

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