Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling.

Fava E, Dehghany J, Ouwendijk J, Müller A, Niederlein A, Verkade P, Meyer-Hermann M, Solimena M

Knowledge of number, size and content of insulin secretory granules is pivotal for understanding the physiology of pancreatic beta cells. Here we re-evaluated key structural features of rat beta cells, including insulin granule size, number and distribution as well as cell size.

Journal, Issue, Date: Diabetologia 2012 Apr 18;55(4):1013-23
Year: 2012
Research Area: Imaging Technologies Development
PubMed ID: 22252472
PubMed link: PubMed

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