Biopolis Dresden Imaging Platform

Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling.

Fava E, Dehghany J, Ouwendijk J, Müller A, Niederlein A, Verkade P, Meyer-Hermann M, Solimena M

Knowledge of number, size and content of insulin secretory granules is pivotal for understanding the physiology of pancreatic beta cells. Here we re-evaluated key structural features of rat beta cells, including insulin granule size, number and distribution as well as cell size.

fig.2 taken from Fava et al, 2012.
  • Diabetologia 2012 Apr 18;55(4):1013-23
  • 2012
  • Imaging Technologies Development
  • 22252472
  • PubMed
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