Biopolis Dresden Imaging Platform

A general theoretical framework to infer endosomal network dynamics from quantitative image analysis.

Foret L, Dawson JE, Villaseñor R, Collinet C, Deutsch A, Brusch L, Zerial M, Kalaidzidis Y, Jülicher F

Endocytosis allows the import and distribution of cargo into a series of endosomes with distinct morphological and biochemical characteristics. Our current understanding of endocytic cargo trafficking is based on the kinetics of net cargo transport between endosomal compartments without considering individual endosomes. However, endosomes form a dynamic network of membranes undergoing fusion and fission, thereby continuously exchanging and redistributing cargo. The macroscopic kinetic properties, i.e., the properties of the endosomal network as a whole, result from the collective behaviors of many individual endosomes, a problem so far largely unaddressed.

Fig.2 taken from Foret et al, 2012.
  • Curr. Biol. 2012 Aug 7;22(15):1381-90
  • 2012
  • Imaging Technologies Development
  • 22748321
  • PubMed

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