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Differential pH-dependent cellular uptake pathways among foamy viruses elucidated using dual-colored fluorescent particles.

Stirnnagel K, Schupp D, Dupont A, Kudryavtsev V, Reh J, Müllers E, Lamb DC, Lindemann D

It is thought that foamy viruses (FVs) enter host cells via endocytosis because all FV glycoproteins examined display pH-dependent fusion activities. Only the prototype FV (PFV) glycoprotein has also significant fusion activity at neutral pH, suggesting that its uptake mechanism may deviate from other FVs. To gain new insights into the uptake processes of FV in individual live host cells, we developed fluorescently labeled infectious FVs.

Fig.1 taken from Stirnnangel et al, 2012.
  • Retrovirology 2012 Aug 30;9:71
  • 2012
  • Medical Biology
  • 22935135
  • PubMed

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