Biopolis Dresden Imaging Platform

Formation of osteoclasts on calcium phosphate bone cements and polystyrene depends on monocyte isolation conditions.

Bernhardt A, Schumacher M, Gelinsky M

Peripheral blood mononuclear cells (PBMC) are an attractive source for the generation of osteoclasts in vitro, which is an important prerequisite for the examination of resorption and remodeling of biomaterials. In this study, different preparation methods are used to obtain cell populations with a rising content of CD14(+) monocytes. We wanted to address the question whether there is a correlation between content of CD14(+) cells in the preparation and functionality of formed osteoclasts.

Fig.6 taken from Bernhardt et al, 2015.
  • Tissue Eng Part C Methods 2015 Feb 22;21(2):160-70
  • 2015
  • Medical Biology
  • 24919531
  • PubMed

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