Biopolis Dresden Imaging Platform

Characterization of a mouse model with complete RPE loss and its use for RPE cell transplantation.

Carido M, Zhu Y, Postel K, Benkner B, Cimalla P, Karl MO, Kurth T, Paquet-Durand F, Koch E, Münch TA, Tanaka EM, Ader M

Age-related macular degeneration (AMD) is a major leading cause of visual impairment and blindness with no cure currently established. Cell replacement of RPE is discussed as a potential therapy for AMD. Previous studies were performed in animal models with severe limitations in recapitulating the disease progression. In detail, we describe the effect of systemic injection of sodium iodate in the mouse retina. We further evaluate the usefulness of this animal model to analyze cell-specific effects following transplantation of human embryonic stem cell (hESC)-derived RPE cells.

Fig.7 taken from Carido et al, 2014.
  • Invest. Ophthalmol. Vis. Sci. 2014 Aug 07;55(8):5431-44
  • 2014
  • Medical Biology
  • 25103259
  • PubMed

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