Biopolis Dresden Imaging Platform

The balance of prickle/spiny-legs isoforms controls the amount of coupling between core and fat PCP systems.

Merkel M, Sagner A, Gruber FS, Etournay R, Blasse C, Myers E, Eaton S, Jülicher F

The conserved Fat and Core planar cell polarity (PCP) pathways work together to specify tissue-wide orientation of hairs and ridges in the Drosophila wing. Their components form intracellularly polarized complexes at adherens junctions that couple the polarity of adjacent cells and form global patterns. How Fat and Core PCP systems interact is not understood. Some studies suggest that Fat PCP directly orients patterns formed by Core PCP components. Others implicate oriented tissue remodeling in specifying Core PCP patterns.

GA. taken from Merkel et al, 2014.
  • Curr. Biol. 2014 Sep 22;24(18):2111-23
  • 2014
  • Developmental Biology
  • 25201685
  • PubMed

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LMF MPI-CBG

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